What is KYBELLA®?
KYBELLA® is a prescription medicine used in adults to improve the appearance and profile of moderate to severe fat below the chin (submental fat), also called
“double chin.”
It is not known if KYBELLA® is safe and effective for the treatment of fat outside of the submental area or in children under 18 years of age.

Who should not receive KYBELLA®?
Do not receive KYBELLA® if you have an infection in the treatment area.

Before receiving KYBELLA®, tell your healthcare provider about all of your medical conditions, including if you:
Have had or plan to have surgery on your face, neck, or chin; have had cosmetic treatments on your face, neck, or chin; have had or have medical conditions in or near the neck area; have had or have trouble swallowing; have bleeding problems; are pregnant or plan to become pregnant (it is not known if KYBELLA® will harm your unborn baby); are breastfeeding or plan to breastfeed (it is not known if KYBELLA® passes into your breast milk).

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that prevents the clotting of your blood (antiplatelet or anticoagulant medicine).

What are the possible side effects of KYBELLA®?
KYBELLA® can cause serious side effects, including

  • Nerve injury in the jaw (which can cause an uneven smile or facial muscle weakness)
  • Trouble swallowing
  • Injection site problems including: bruising, hair loss, open sores (ulcers), damage and tissue cell-death (necrosis) around the injection site. Call your healthcare provider if you develop open sores or drainage from the treatment area

The most common side effects of KYBELLA® include swelling, pain, numbness, redness, and areas of hardness in the treatment area.
These are not all of the possible side effects of KYBELLA®. Call your doctor for medical advice about side effects.

Please see KYBELLA® full Prescribing Information.
Please see accompanying full Prescribing Information, or ask your healthcare provider, or visit

KYB1113215 01/18 180481

How to get rid of a double chin?

There are many simple exercises for a double chin.

While there is little scientific research on the effect of these exercises, they target the muscles of the neck and face. Working these muscles could help burn fat in these areas, and may be a crucial part of getting rid of a double chin.

Around the world (warm up)

As with any exercise routine, it is important to warm up the muscles to avoid injury. To warm up the neck, gently rotate the head forward and down and then back and up using a clockwise, circular motion. After a few rotations, reverse the direction.

The same circular motion is used to stretch the jaw. Gently extend the jaw left, then forward, then right, and then back, holding each position for a second or two. Now the muscles are warmed and ready for exercise.

Whistle at the ceiling

This exercise is great for strengthening the muscles and giving the neck a break during time spent at the desk. Sit with a straight back and relaxed shoulders.

Tilt the head back to look at the ceiling. From this position, close the lips into the position used while whistling. The lips should be relaxed but held tight enough to feel a contraction on both sides of the neck.

Hold this position for 10 to 20 seconds depending on the comfort level of the individual. Ten repetitions of this exercise are usually enough for one sitting.

Kiss the sky

Share on PinterestIn this exercise, try to get the lips as far from the face as possible.

This exercise is similar to the previous one, with a few differences.

Stand straight and tall with the arms and shoulders loose and relaxed. Tilt the head back to look at the ceiling. Pucker the lips and try to kiss the sky, extending them as far away from the face as possible.

When done correctly, the muscles throughout the neck and chin should feel flexed but comfortable. Hold this position for 5 to 20 seconds and then relax. Repeat 10 to 15 times per set.

The ball squeeze

Keeping an exercise tool on hand is an excellent way to help some people remember to do their exercises.

For neck exercises, it may help to keep a ball somewhere near the desk, bed, or in a place where a person will do the exercises. The size of the ball can range from 5 to 10 inches based on personal comfort and should be easy to squeeze.

The ball squeeze is done best from a seated position with a straight back and relaxed shoulders.

Place the ball under the chin. Use the chin to push down against the ball in a steady, firm motion. This can be repeated 10 to 30 times during each sitting.

The pouting stretch

Another effective way to target the muscles in the chin and neck is to do a pouting stretch.

Standing or seated, stick the bottom lip out as far as possible to form a pouting face. Hold the position for 3 seconds. With the lip still in full pout, use the muscles of the neck to tilt the chin towards the chest without moving the upper back.

Hold this position for 3 seconds. Relax the muscles and start again. Repeat 10 to 20 times or until the neck feels the workout.

Gum chewing

Chewing gum may not seem like much, but it may be useful for people looking to get rid of a double chin in multiple ways.

A study posted to the journal Appetite found that individuals who chew gum after a meal may feel more satisfied with what they have eaten. This makes them less likely to reach for additional snacks. Chewing gum can help people who are losing weight to reduce the number of calories in their diet.

Chewing gum is a minor workout for the muscles of the face, especially the jaw. Regular gum chewing may contribute to an overall loss of fat in the chin though it probably will not do much by itself.

The lion’s yawn

Share on PinterestThis exercise should mirror a lion’s yawn, with the tongue extending as far as possible.

The point of this exercise is to open the mouth wide while sticking the tongue out as far as possible, much like a yawning lion.

It can be a great exercise to strengthen many muscles in the chin, neck, and face.

Sit or stand with a relaxed posture. Open the mouth as wide as possible while extending the tongue out as far as it will go.

When done correctly, the muscles of the neck, chin, and jaw should tighten.

Push the tongue out for 10 seconds and relax. Repeat this process 10 times and move on to another exercise.


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Apr. 30, 2015 — A shot that dissolves fat will offer people with a double chin a way to get rid of it without surgery.

The FDA approved the new drug, called Kybella, on Wednesday. It will be available in cosmetic surgeons’ and dermatologists’ offices in June.

Here’s what you need to know.

What is the treatment and how does it work?

Kybella is identical to something your body makes called deoxycholic acid, which helps to absorb fats, the FDA says.

It works by destroying fat cells. It can also destroy other kinds of cells, including skin cells, if it’s not used correctly, the FDA says.

The shot is an alternative to liposuction or surgery to treat double-chin fat.

Why is it needed?

“Upwards of 80% of people are concerned about the condition,” says

Derek H. Jones, MD, an associate clinical professor of dermatology at UCLA’s David Geffen School of Medicine. Jones was the lead investigator in a study sponsored by the drug’s maker, Kythera Biopharmaceuticals.

How many rounds of treatment do you need, and what results should you expect?

It varies. Alan Matarasso, MD, a plastic surgeon in Manhattan, thinks patients will need a series of 12-20 injections per visit. You may need two to three total visits, spaced a month apart. Each treatment takes about 15 minutes.

Some people may get up to 50 injections in a single treatment, with up to six single treatments no less than a month apart, the FDA says. Many people saw results in two to four treatments, according to Kythera.

Although it’s not approved for saggy skin, can it help tighten it?

Experts don’t agree. “It doesn’t tighten your skin. It is there to melt fat,” Matarasso says. But Jones says some people did notice a tightening effect.

Before approving the drug, the FDA looked at the results of two U.S. trials that included more than 1,000 people. Those who got the drug more often saw less fat under the chin. More than 80% of those getting the drug said they noticed some improvement in their chin fat, the company says.

PITTSBURGH — Double chin got you down? Soon you may be able to get a shot for that.

CBS Pittsburgh’s Dr. Maria Simbra reports an FDA advisory panel has unanimously recommended approval of an injectable drug for treating double chins. The drug, deoxycholic acid, dissolves fat, and in studies of injections under the chin, MRI scans showed decreased fat over several weeks.

If it wins final FDA approval, the drug could offer a less invasive, lower cost alternative to plastic surgery. The only options currently available for reducing double chins include neck lifts and liposuction, which can cost $800 to $2,500.

“The trend has been finding things that are non-invasive, with little to no risk, little to no down time, that can make an improvement,” says plastic surgeon Dr. Leo McCafferty.

He also points out the drug would be easy for many doctors to offer. “It doesn’t involve a very expensive piece of equipment, like a laser which might cost $100,000. It involves a syringe, the product and the needle.”

The injections are best suited for those with good skin tone. The product will not tighten loose skin, but will shrink a small pouch of fat.

“I think this is just another tool that we’ll have, but it isn’t going to be a panacea for all double chins,” McCafferty emphasized.

While pricing has not yet been worked out, it will likely have a similar cost to Botox.

No matter what the expense, it’s all too much for some folks.

“I would just go run outside, and get rid of it, rather than doing anything artificial,” said one woman.

“I think it’s ridiculous. Just live with what you have,” another man said.

The FDA’s final decision is expected in May. The FDA usually follows the recommendations of its advisory panels.

Fat-dissolving treatments for a double chin

Many people are bothered by double chins and try to conceal them behind turtleneck shirts and scarves. However, recent advancements have expanded the options for jowl removal beyond surgery to in-office treatments.

Cryolipolysis (Cool Mini)

This procedure, also known as “cool sculpting,” treats a double chin. The clinician places a handpiece under the chin and chills fat cells there almost to the point of freezing, damaging their membranes so they are absorbed and metabolized by the body. The treatment itself takes about an hour, and results are seen over the subsequent two months. The procedure is usually effective and can be performed more than once. It can also be used to reduce love handles on the waist. The cost is approximately $1,000 per treatment.

Injections to damage fat (Kybella)

This product, approved by the FDA in 2016, contains a substance that damages fat cells. After applying local or topical anesthesia, the physician selects 10 to 15 injection sites in the neck area. The shots can be slightly uncomfortable, and there is potential for swelling, pain, and redness for one week. The fat under the chin will disappear over the course of the next four to six weeks. Like cryolipolysis, these injections are usually effective and can be repeated two or three times. The cost is similar, too: about $1,000.

To learn more about other cosmetic procedures and ways to care for your skin, buy Skin Care and Repair, a Special Health Report from Harvard Medical School.

Image: © DAJ | Thinkstock

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

Just a couple months ago, we told you about Kybella—a new injectable that can minimize the appearance of a double chin with just a couple of treatments. It’s since been gaining popularity. And now, there’s another option available: CoolSculpting. The FDA recently expanded its approval of the treatment for smaller areas on the body, like the spot under your chin (previously it was only approved for spots like your stomach and thighs), with a new applicator called CoolMini.

Now the question is, how do the two stack up to each other? We reached out to three experts on the topic: Los Angeles Dermatologist Dr. Ava Shamban, Los Angeles plastic surgeon Grant Stevens, M.D., and national spokesman for the American Society of Plastic Surgery, New York plastic surgeon Barry Weintraub, M.D., to find out. (For the record, we’re not saying you have to run out and try either; you’re beautiful as is! But if you are curious about noninvasive treatments, we’re here to give you the facts.)

How they work:

You can get a full rundown on Kybella here, but here’s the CliffsNotes version: It’s an FDA-approved injection containing a naturally occurring molecule that dissolves fat, which your body then flushes out. Essentially it “bursts fat cells with medication,” says Dr. Shamban. The best candidate is someone with good skin and a very distinct appearance of fat under the chin.

CoolMini is a new FDA-approved attachment for Coolsculpting—a procedure that freezes fat cells away. (More specifically: It creates ice crystals in fat cells, which ultimately destroys them.) One session takes roughly an hour and can freeze up to 1/3 of the fat from under your chin. Dr. Stevens says it’s a particularly great treatment for those who dislike injections: “There are no needles involved, and there’s no downtime.” The treatment works best for women with looser, more mature skin. “With the CoolMini, the affected area needs to be sucked up into the hand piece while it’s being chilled,” says Dr. Shamban. “There may be a limitation with a younger neck because the skin too taut.”

Final results for both procedures typically appear within one to two months.

The side effects:

Whichever route you go, Dr. Shamban says expect to some swelling in your neck. Soreness too. With Kybella, there’s also a chance the area will feel numb for up to a month and will be red for a few days. There could be numbness and redness with the CoolMini as well, but it disappears a little sooner. Another possible (but rare) side effect of CoolMini? “The applicator might not cover enough of the desired area, and it’s difficult to taper off the sides, so theoretically you might have a shelf effect,” says Dr. Shamban. Meaning, you could get an indentation where the fat was killed off, but the surrounding fat will remain.

The cost:

The more affordable option really comes down to the number of sessions needed. Kybella typically requires a series of three treatments (each four to six weeks apart), which costs around $5,400 in total. CoolMini costs about $1,000 per treatment. “Most people need one or two CoolMini treatments, depending on the amount of fat under the chin,” says Dr. Weintraub.

Bottom line: If you’re interested in either treatment, your best bet is to talk to your doctor to discuss which is right for you.


Want to know what’s trending in beauty now? Check the Lipstick Index:

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Demand is crazy for drug that melts away double chin fat

Double chins, beware.

The unsightly facial feature that has plagued people of all shapes and sizes has finally met its match, thanks to a newly approved remedy.

Kybella, a fat-melting injectable drug created by Kythera Biopharmaceuticals Inc., was approved by the FDA in April and became available June 15 to dermatologists and plastic surgeons who completed training at the drug company’s Westlake Village, Calif., offices.

Kybella is made from deoxycholic acid, which is a chemical produced in the body to help absorb fats. When injected into the fat below the chin, known as submental fat, it destroys the fat cells. Patients can receive up to 50 injections in one single treatment, with up to six treatments administered no less than one month apart.

“I’ve never seen a demand like this, except for Botox,” Derek Jones, a dermatologist on the faculty at UCLA and lead investigator in the clinical FDA trials of Kybella, told the Hollywood Reporter. “We have a waiting list of people who have been calling for months.”

The brains behind Botox have taken notice. Allergan, the pharmaceutical company that owns the wrinkle-smoothing drug, is set to acquire Kythera Biopharmaceuticals this week for $2.1 billion.

It’s a worthwhile investment. Though pricing on Kybella hasn’t yet been released, professionals estimate that it will cost between $500 and $600 per treatment. Manhattan plastic surgeon Alan Matarasso believes patients should expect to make two or three total visits, spaced a month apart.

Comparatively, liposuction for double chins routinely costs between $1,500 and $2,000.

According to Kybella’s website, 79 percent of patients treated with Kybella reported satisfaction with the appearance of their face and chin, as well as a marked improvement in self-perception.

Possible side effects including swelling, bruising, pain, numbness, redness, difficulty swallowing and nerve injury in the jaw that cases facial muscle weakness. If injected incorrectly, it could destroy the wrong kinds of cells — including skin cells.

“Kybella should not be used outside of the submental area,” warns the FDA — not that everyone is heeding the warning.

“Now that it’s FDA-approved, approved doctors are allowed to use it ‘off label,’ which means we can attempt it with discretion on other places,” dermatologist Peter Kopelson reveals to the Hollywood Reporter. “I suspect it will be for targeted use, like love handles, under-eye fat pockets and fat above the knees — something even young women complain about.”

Pill for double chin

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